Immunological Responses to Helminths and HIV-1 CoInfections

Aim: Helminth infections result from poor sanitation. We evaluated the effect of helminth on HIV disease progression through monitoring 2 outcomes: (1) plasma HIV-1 RNA Viral load (V/L) and (2) Cluster Differentiation (CD4+) T-lymphocyte count amongst helminth-HIV-1 co-infected persons. hypothesized that concurrent compromise immune control, resulting in rising VL reduced CD4+ that, subject to successful treatment, a decrease could slow down progression. Methods: reviewed 2032 citations, 432 abstracts, included 10 articles according PRISMA diagram. The methodologies were appraised using Mixed Method Appraisal Tool (MMAT). Results: At enrolment, was significantly higher individuals with helminths (5.01 log10 vs. 3.41 log10, p < 0.001). effective range 5.28 copies/mL at baseline 4.67 copies/mL, (p 0.05) after treatment trend for 0.61 lower VL. Significant interactions seen successfully treated groups values not different co-infection relative those infection alone.
 Conclusion: Helminths co-infections are associated an increase levels accelerate sub-clinical symptomatic AIDS.